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KMID : 1130320090520010087
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Korean Journal of Pediatrics
2009 Volume.52 No. 1 p.87 ~ p.92
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The relationship between catechol-O-methyltransferase gene polymorphism and coronary artery abnormality in Kawasaki disease
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Lee Hyo-Jin
Lee Myung-Sook
Kim Ji-Suk
Kim Eun-Ryoung
Kang Sung-Wook
Kim Soo-Kang
Chung Joo-Ho
Yoon Kyung-Lim
Han Mi-Young
Cha Sung-Ho
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Abstract
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Purpose: Many gene polymorphisms are associated with coronary artery abnormalities in Kawasaki disease. Catechol-O- methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catechol estrogen, and catechol drugs. Polymorphisms of the COMT gene are reported to be associated with myocardial infarction and coronary artery abnormalities. The aim of this study was to evaluate the relationship between COMT gene polymorphisms and coronary artery abnormalities in Kawasaki disease patients.
Methods: One hundred and one Korean children with Kawasaki disease and 306 healthy Korean control subjects were enrolled in this study. The polymorphisms of the COMT gene were analyzed by direct sequencing.
Results: There were no differences in the genotype and allelic frequency of the rs4680 and rs769224 polymorphic sites between Kawasaki disease and control subjects. Further, no significant difference was found in the rs4680 polymorphism between patients with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P=0.32, dominant P=0.74, recessive P=0.13). However, the distribution of the rs769224 polymorphism was significantly different between patients with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P= 0.0077, dominant P=0.0021, recessive P=0.16).
Conclusion: Our results indicate that the polymorphisms of the rs769224 gene might be related to the development of coronary artery abnormalities in Kawasaki disease.
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KEYWORD
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Mucocutaneous lymph node syndrome, Kawasaki disease, Coronary artery disease, Genetic polymorphism, Catechol-O-Methyltransferase
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